tag:blogger.com,1999:blog-39202537845569654912011-09-05T02:23:18.127-07:00IU Center for Regenerative Biology and Medicinehttp://www.blogger.com/profile/03396140825705655293noreply@blogger.comBlogger21100tag:blogger.com,1999:blog-3920253784556965491.post-63483362219337158582009-03-10T21:01:00.000-07:002009-03-10T21:22:19.914-07:00<p>Regenerative Biology and Medicine is a rapidly developing field that will have a substantial impact on the life and health sciences in the 21st century.</p><p align="left"><img id="BLOGGER_PHOTO_ID_5311780606578493858" style="DISPLAY: block; MARGIN: 0px auto 10px; WIDTH: 400px; CURSOR: hand; HEIGHT: 106px; TEXT-ALIGN: center" alt="" src="http://2.bp.blogspot.com/_zTSQapt0GAc/Sbc8UZPriaI/AAAAAAAAABk/X8s9LNSQgLw/s400/photo_02b.jpg" border="0" /><br /><strong>Regenerative Biology</strong> is the study of the mechanisms by which organisms regenerate tissues naturally. </p><div><strong>Regenerative Medicine</strong> is the application of this knowledge to regenerate tissues that do not regenerate naturally, or which are so badly damaged that natural mechanisms of regeneration fail to restore them. </div><div><br />Learn more about the <a href="http://regen.iupui.edu/">Indiana University Center for Regenerative Biology &amp; Medicine</a>.</div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/3920253784556965491-6348336221933715858?l=regenerativebiology.blogspot.com' alt='' /></div>IU Center for Regenerative Biology and Medicinehttp://www.blogger.com/profile/03396140825705655293noreply@blogger.com1tag:blogger.com,1999:blog-3920253784556965491.post-37867430812699839142009-03-10T17:06:00.000-07:002009-11-30T14:25:22.958-08:00<a href="http://3.bp.blogspot.com/_zTSQapt0GAc/SbctcRwcw5I/AAAAAAAAABE/clKjGfIZmqo/s1600-h/dai.png"><img id="BLOGGER_PHOTO_ID_5311764249332990866" style="margin: 0px 0px 10px 10px; float: right; width: 200px; height: 255px;" alt="" src="http://3.bp.blogspot.com/_zTSQapt0GAc/SbctcRwcw5I/AAAAAAAAABE/clKjGfIZmqo/s320/dai.png" border="0" /></a><br /><div><strong style="font-size: 130%;">Guoli Dai, DVM, PhD</strong><br /><br /><em>Assistant Professor of Biology</em><br /><br />Department of Biology, School of Science<br />Indiana University-Purdue University Indianapolis<br />723 W. Michigan Street<br />Indianapolis, IN 46204<br /><br /><strong>RESEARCH INTERESTS</strong><br />My laboratory investigates the molecular mechanisms regulating hepatocyte proliferation and liver growth in both physiological and pathological conditions. The maternal liver adapts to pregnancy by marked growth manifested by hepatocyte proliferation and liver size increase. We are particularly interested in revealing the role of placental hormones in mediating the hepatic growth response to pregnancy. In response to acute or chronic liver injuries, the liver regenerates, repairing damaged tissue and restoring original structures and functions. The hepatic regenerative response is a phenomenon of compensatory growth of injured liver. Timely and/or enhanced hepatocyte proliferation leads to recovery from liver injury and survival, whereas delayed and/or inhibited hepatocyte proliferation in pathological conditions results in liver failure and death. We are studying the functions of transcription factors that can be activated by a pharmacological approach in modulating hepatocyte proliferation during liver regeneration. Our goal is to develop a clinical strategy to rescue injured livers by targeting hepatocyte proliferation and thereby liver repair.<br /><br /><strong>RECENT PUBLICATIONS</strong><br />G Dai, L Lu, S Tang, N Sahgal, and M Soares. 2002. Prolactin Family Miniarray: A Tool for Evaluating Uteroplacental-trophoblast Endocrine Cell Phenotypes. Reproduction, 24(6):755-65.<br /><br />R Ain, G Dai, J Dunmore, A Godwin, and M Soares. 2004. A Prolactin Pamily Paralog Regulates Reproductive Adaptations to A Physiological Stressor. Proc. Natl. Acad. Sci. U S A., 23;101(47):16543-8.<br /><br />G Dai and YJ Wan. 2005. Animal Models of Xenobiotic Receptors. Current Drug Metabolism, 6(4):341-355.<br /><br />G Dai, N Chou, L He, MA Gyamfi, JA Mendy, AL Slitt, CD Klaassen, and YJ Wan. 2005. Retinoid X Receptor Alpha Regulates the Expression of Glutathione S-transferase Genes and Modulates Acetaminophen-glutathione Conjugation in Mouse Liver. Molecular Pharmacology, 68(6):1590-1596.<br /><br />G Dai, N Chou, L He, and YJ Wan. 2006. Acetaminophen Metabolism Does Not Contribute to Gender Difference in Its Hepatotoxicity in Mouse. Toxicological Sciences, 92(1):33-41.<br /><br />SM Alam, T Konno, G Dai, L LU, D Wang, JH Dunmore, AR Godwin, MJ Soares. 2007. A Uterine Decidual Cell Cytokine Ensures Pregnancy-dependent Adaptations to A Physiological Stressor. Development, 134(2):407-15.<br /><br />J Bustamante, G Dai, and MJ Soares. 2008. Pregnancy and Lactation Modulate Maternal Splenic Growth and Development of the Erythroid Lineage in the Rat and Mouse. Reproduction, Fertility and Development, 20(2):303-310<br /><br />G Dai, L He, P Bu, and YJ Wan. 2008. Pregnane X Receptor Is Required for Normal Progression of Liver Regeneration. Hepatology, 47(4):1276-1287</div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/3920253784556965491-3786743081269983914?l=regenerativebiology.blogspot.com' alt='' /></div>IU Center for Regenerative Biology and Medicinehttp://www.blogger.com/profile/03396140825705655293noreply@blogger.com3